In particular, during PCa development, the overexpression of MMP-1, -2, -7, -9, and -14 was found in stroma and circulation [85,86], as well as an imbalance between MMPs and tissue inhibitors of matrix metalloproteinases (TIMPs), which enhances PCa cell invasiveness [87,88]. This evidence concerns the gene MMP1 and posterior cortical atrophy.