To overcome this problem, several AKI biomarkers, including NGAL, KIM-1, IL-18, L-FABP, and TIMP-2*IGFBP-7, have been identified to predict the onset of AKI, AKI severity, and renal prognosis of AKI in critically ill patients [37]. The gene discussed is IGFBP7; the disease is acute kidney injury.