Experiments with human cancer cells confirmed that a significant proportion of HIF-1-dependent genes relied on Tip60 for their induction by hypoxia and demonstrated physical association between HIF-1α and components of the Tip60 complex, including Tip60 itself, the catalytic subunit with lysine acetyl transferase (KAT) activity, Reptin and Pontin. This evidence concerns the gene KAT5 and cancer.