HIF1A and breast cancer: PKM2 was also shown to associate with JMJD5, a JMJD protein with lysine demethylation and hydroxylation activity, and their complex promoted HIF-1 transcriptional activity in breast cancer cells, while JMJD5 and PKM2 were co-recruited to HREs of two known HIF-1 target genes enhancing HIF-1α binding [60].