In the case of multiple myeloma, mutations are also reported in many other signalling subunits of non-canonical NF-κB pathway—NF-κB2, TRAF2, TRAF3, BTRC encoding β-TrCP, which alters the inhibitory degradative pathway of NIK kinase by TRAF2/TRAF3 complex, leading to malignancy-associated activation of non-canonical NF-κB signalling [150]. Here, BTRC is linked to plasma cell myeloma.