The canine model of MPS VII has also shown promising therapy results following rAAV-GUSβ intrathecal injection of serotypes 9 and the NHP-derivate AAVrh10 [221], as high expression levels of GUSβ were detected in the CNS tissues, with the enzyme in brain tissue homogenates showing over 100% normal activity. The gene discussed is GUSB; the disease is mucopolysaccharidosis type 7.