Profibrotic signaling, such as TGF-β, MAPK, and ERK signaling, is activated in Lmna H222P/H222P mice, and the partial inhibition of ERK and JNK signaling before the onset of cardiomyopathy in Lmna H222P/H222P mice significantly reduces cardiac fibrosis and prevents the development of left ventricle dilatation and decreased cardiac ejection fraction [138,139,140,141]. This evidence concerns the gene MAPK8 and cardiomyopathy.