Mutations in desmosomal genes, such as Plakophilin 2 (PKP2), Desmoplakin (DSP), Desmoglein 2 (DSG2), Desmocollin 2 (DSC2), and junction plakoglobin (JUP), are the main cause of ARVC [93,94,95,96,97,98]. The gene discussed is JUP; the disease is Arrhythmogenic right ventricular dysplasia.