APP and early-onset autosomal dominant Alzheimer disease: Five familial Alzheimer’s Disease (5xFAD) is an APP/PS1 mouse model co-expressing five familial AD gene mutations (APP—K670N/M671L [Swedish] + I716V [Florida] + V717I [London]; PS1—M146L + L286V), which have the combined effect of rapidly driving disease pathology that recapitulates the characteristics of AD [8].