In APS, endocytosis of antiphospholipid antibodies (aPLs) into pDCs induces TLR7/8-dependent type I IFN production [129], as characterized by increased expression of TLR7 [130] and TLR8 [131] in PBMCs from patients with APS. This evidence concerns the gene TLR7 and autoimmune polyendocrinopathy.