This OR seems to be directly linked to the severity of GBA mutations; indeed, severe GBA mutations (i.e., L444P, IVS2+1G>A, c.84dupG, V394L, D409H, RecTL, RecNCil) are associated with a higher risk of PD compared to mild ones (i.e., N370S) [25]. This evidence concerns the gene GBA1 and Parkinson disease.