CASP3 and neuroblastoma: This observation is consistent with our previous studies showing that M30 decreased apoptosis of SH-SY5Y neuroblastoma cells when given after depriving the cells of serum support (neurorescue paradigm) via various protective mechanisms, including reduction in the pro-apoptotic proteins, Bad and Bax, and inhibition of the apoptosis-associated phosphorylated H2A.X protein (Ser-139) and caspase-3 activation [127].