VEGFA and amyotrophic lateral sclerosis: Deletion of the hypoxia-responsive element in the promotor region of the VEGF gene can cause motor degeneration in mice, and low-VEGF-producing alleles of the VEGF gene are associated with motoneuron degeneration in human ALS, suggesting that VEGF is a modifier of motoneuron degeneration in human ALS [214,215,216].