Since increased expression of the cyclin system may be involved in the mechanism of motor neuronal death at the late stage of ALS, it is reasonable to suggest that drugs directed towards cell cycle inhibition might be of value for disease treatment; (c) activation of HIF-1 and induction of its pro-survival/neuroprotective target genes (e.g., VEGF and enolase 1), an action that has been ascribed to iron chelation and inhibition of PHDs. The gene discussed is HIF1A; the disease is amyotrophic lateral sclerosis.