CTNNB1 mutation activated the β-catenin pathway, and the presence of β-catenin nuclear staining caused by activation of the Wnt/β-catenin signaling pathway led to reduced OS and disease-free survival in ACC [83,84], supporting that CTNNB1 mutation was associated with a poor prognosis in this study. Here, CTNNB1 is linked to adrenal cortex carcinoma.