3.5. Pon1 Gene Silencing Downregulates the Histone Demethylase Phf8, Upregulates H4K20me1 Epigenetic Mark, mTOR and pmTOR, APP, and Inhibits Autophagy in Mouse Neuroblastoma N2a-APPswe Cells. The gene discussed is PHF8; the disease is neuroblastoma.