Although Pon1 depletion in mouse neuroblastoma N2a-APPswe cells downregulated Phf8 (Figure 1A and Figure 2A) and upregulated APP (Figure 1H and Figure 2A) and Aβ (Figure 5), depletion of Phf8 upregulated Aβ but not APP [42]. The gene discussed is PHF8; the disease is neuroblastoma.