Because dysregulated mTOR signaling and autophagy have been implicated in Aβ accumulation in Alzheimer’s disease [31,32], and H4K20me1 demethylation by PHF8 is important for maintaining homeostasis of mTOR signaling [33], we studied how these processes are affected by Pon1 depletion in the mouse neuroblastoma N2a-APPswe cells and Pon1─/─5xFAD mice. This evidence concerns the gene PON1 and Alzheimer disease.