MiRNAs deregulation linked with AD in two ways; (i) the deregulation of miRNAs could be initiated by AD pathogenic factors such as Aβ, p-tau, inflammation, aging, oxidative stress, and mitochondrial DNA damage, and/or (ii) the genetic alteration of miRNAs could be a contributing factor in AD progression. The gene discussed is MAPT; the disease is Alzheimer disease.