More detailed data were provided by studies on a transcriptional level, including the finding that proinflammatory gene profiles had higher expression levels of IL-8, FBJ murine osteosarcoma viral oncogene homolog B (FOSB), cluster of differentiation 83 (CD83), suppressor of cytokine signaling 3 (SOCS3), chemokine (C-X-C motif) ligand 1 (CXCL1) and CXCL2 in monocytes of ALS patients compared to healthy controls [127]. This evidence concerns the gene SOCS3 and amyotrophic lateral sclerosis.