Likewise, Tagitinin C, another natural compound, induces ferroptosis in colorectal cancer cells through the PERK–NRF2–HMOX1 signaling pathway, and again the significant overexpression of HMOX1 led to the increase in the LIP, which promoted lipid peroxidation and ferroptosis [53]. The gene discussed is EIF2AK3; the disease is colorectal cancer.