There are molecules secreted by CAFs that regulate the expression of lncRNAs in tumor cells as reported by Zhang et al., reporting that the Midkine molecule (MK) secreted by the tumor stroma regulates the expression of the lncRNA ANRIL and participates directly in the resistance to cisplatin, showing that CAF-conditioned medium in stimulated cancer cells induces cisplatin resistance, thus suggesting that the MK secreted by CAFs in a paracrine manner towards tumor cells regulates the resistance to cisplatin by inhibiting apoptosis [68]. The gene discussed is CDKN2B-AS1; the disease is neoplasm.