Based on the literature and our current data that demonstrate a significant reduction in LOX, PTCH1, COL22A1, FOXO1, and HMGA2 in the IECs of sepsis mice, compared to sham mice (Figure 8), the sepsis-augmented miRNAs in the IECs may have the potential for regulating both anti- and pro-inflammatory responses, possibly through posttranscriptional modification of their functional target genes. This evidence concerns the gene COL22A1 and Sepsis.