Thus, in a recent study conducted on 65 patients carrying the monoallelic LMNA p.(Thr655Asnfs*49) variant and 13 carrying the same biallelic variant, while 54% of heterozygous subjects were diagnosed during family screening, 69% of homozygous patients were diagnosed due to medical complications, all of them presenting obvious clinical features of lipodystrophy [16]. This evidence concerns the gene LMNA and lipodystrophy.