LEP and Hyperglycemia: In fact, when comparing patients with FPLD2 with severe hypoleptinaemia (serum leptin <7th percentile of normal) vs. those with moderate hypoleptinaemia (serum leptin in 7–20th percentiles) leptin replacement therapy was found to be equally effective in reducing serum and hepatic triglyceride levels, with no improvement in hyperglycaemia [140].