If heterozygous and homozygous patients are compared, homozygous subjects harbouring the p.(Thr655Asnfs*49) variant in exon 11 of the LMNA gene presented more overlapping syndromes with severe cardiac phenotypes (early atheroma with coronary heart disease, conduction or rhythm disorders, dilated cardiomyopathy, heart failure with left ventricle lowered ejection fraction and an earlier onset of these cardiac manifestations in comparison with heterozygous subjects with the same variant) [16,120]. The gene discussed is LMNA; the disease is heart failure.