In addition, in a case with the R644C variant in the LMNA gene and in four members of a large pedigree with the pathogenic R349W variant in the same gene, focal segmental glomerulosclerosis was present, with a variable degree of renal dysfunction and proteinuria, suggesting, therefore, a possible role of LMNA in the maintenance of glomerular function and structure [126,127]. This evidence concerns the gene LMNA and focal segmental glomerulosclerosis.