Considering that increased expression of HAGLR is linked to the progression of colon, hepatocellular, and triple negative breast cancer, where RUNX3 is often downregulated [52,53,54], it would be of great interest to determine whether a direct interaction between HAGLR and RUNX3 exists and whether HAGLR could serve as scaffold for an E3 ligase, similar to HOTAIR/Mex3b, to degrade RUNX3 via the UPS in cancer cells. The gene discussed is RUNX3; the disease is cancer.