Intriguingly, extracellular Hsp70 forms an activation complex with different Hsps, including Hsp90α, Hsp70/Hsp90 organizing protein (Hop), and Hsp40, which together enhance the invasion and migration of the breast cancer cells via the upregulation of metalloproteinase-2 (MMP2). The gene discussed is HSP90AA1; the disease is breast carcinoma.