BACE1 and Alzheimer disease: Assuming that BACE1/beta-secretase expression contributes to Aβ accumulation in the brain of other animal models of AD [66,67], it might be possible that lowering the expression of miRNA-29 a/b-3p and -191-5p in FAβ1–42-infused rats might result in an increase of BACE1 expression and consequently Aβ1–42 peptide production by neural cells.