This result is in agreement with the overall expression trends observed when analyzing all N0 and N+ patients shown in Figure 6B. With this in mind, targeting oncofetal FN presents on opportunity to enhance the diagnostic procedures for lymph node activity in head and neck squamous cell carcinoma and has the potential to be applied to other cancers with high rates of lymph node activity as well. Here, FN1 is linked to head and neck squamous cell carcinoma.