FN1 and cancer: On average, FN mRNA exhibits 5.23× overexpression in primary tumors compared to normal tissues among the cancer types analyzed, with the highest overexpression occurring in breast cancer (BRCA, 8.4×), glioblastoma multiforme (GBM, 18.5×), head and neck squamous cell carcinoma (HNSC, 7.4×), pancreatic adenocarcinoma (PAAD, 20.9×), and thyroid cancer (THCA, 41.2×) (Figure 1C).