Grifoni et al. have provided some insights into the mechanisms underlying neo-tracheogenesis in cancer models: in RasV12; lgl wing disc hypoxia is sensed by the Hypoxia-inducible factor 1-alpha (HIF1A) orthologue Similar (Sima), which upregulates Bnl to attract tracheal tubules through their FGF receptor, Breathless (Btl) [65]. The gene discussed is HIF1A; the disease is cancer.