The results showed that SCP-Se NPs could more effectively alleviate LPS-induced diarrhea, intestinal tissue injury, and tight junction destruction and decrease the elevated inflammatory cytokine expression levels of TNF-α, IL-1β, and IL-6 compared with SCP in mouse models, suggesting that SCP-Se NPs can serve as a good candidate for preventing and treating enteritis in the livestock and poultry industry. The gene discussed is IL1B; the disease is enteritis.