Importantly, extract Br.10 which failed to cause neuritotoxicity, also failed to block LTP, and extract Br.9 which caused neuritotoxicity but in a manner independent of Aβ did not affect LTP. This finding is consistent with our prior preliminary study which suggested that a minority of AD brain extracts perturb LTP in a manner dependent on tau 31. Here, MAPT is linked to Alzheimer disease.