Experimental studies have shown that diets enriched with omega-3 polyunsaturated fatty acids increase insulin sensitivity, reduce intrahepatic triglyceride content and ameliorate steatohepatitis [42].Moreover, the Mediterranean diet plays a beneficial role in metabolic profile and has been shown to reduce the risk of cardiovascular disease and diabetes, two outcomes highly relevant in NAFLD patients [43, 44]. This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.