Experimental studies have shown that diets enriched with omega-3 polyunsaturated fatty acids increase insulin sensitivity, reduce intrahepatic triglyceride content and ameliorate steatohepatitis [42].Moreover, the Mediterranean diet plays a beneficial role in metabolic profile and has been shown to reduce the risk of cardiovascular disease and diabetes, two outcomes highly relevant in NAFLD patients [43, 44]. The gene discussed is INS; the disease is diabetes mellitus.