In various cells including macrophages, human and rat smooth muscle cells, human vascular endothelial cells, cardiovascular cells, neuronal cells, cancer cells, and THP-1 derived monocytes statins have been shown by blocking prenylation of Ras and Rho families prevent the formation of NADP-oxidase subunits into a functional unit [59–67]. The gene discussed is RHO; the disease is cancer.