Methyl gallate is also shown to have anti-inflammatory activities in zymosan-induced experimental arthritis animal model, wherein methyl gallate impaired zymosan-stimulated macrophages by inhibiting IL-6 and nitric oxide production, cylooxegenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression (71). Here, NOS2 is linked to arthritic joint disease.