JADE3 and Familial prostate cancer: These findings suggested that circAAGAB could act as a sponge for miR-378 h to up-regulate the expression levels of KIAA1522, NKX3-1, and JADE3. Although KIAA1522 was shown to promote malignancy in hepatocellular carcinoma cells [45], NKX3-1 played the role of tumor suppressor in prostate cancer [46], and JADE3 was found to increase stemness in colon cancer [47], this is the first discovery of their tumor suppressor roles in breast cancer.