AGR2 and Cirrhosis: For OS, univariate analysis showed that cirrhosis (P = 0.023), AFP level (P = 0.011), tumor size (P = 0.001), CLIP score (P < 0.001), BCLC stage (P < 0.001), AJCC stage (P < 0.001), and a high AGR2 level (P = 0.002) were significant predictors of worse OS (Table 3).