Using bioinformatics analysis, we found that the mRNA expression levels of frizzled class receptor 6 (FZD6) and proteasomal subunit α4s (PSMA8), which associated with the Wnt signaling pathway and Alzheimer disease, were downregulated in the vitreous of patients with PDR. Here, PSMA8 is linked to early-onset autosomal dominant Alzheimer disease.