In this post hoc analysis of the MANCTRA-1 study, the association of age > 76 years, history of uncontrolled arterial hypertension, CRP > 125 mg/L, LDH > 510 U/L, renal failure, haemodynamic failure and acute cholangitis diagnosed within 72 h from hospital admission allowed to predict mortality. The gene discussed is CRP; the disease is Renal insufficiency.