For the variant rs3764821 (ALDH3B1), lung cancer patient treated with paclitaxel-cis/carboplatin showed a significantly low OS (AA vs. AG + GG: hazard ratio [HR] = 3.62, 95% CI = 1.03–12.71, p = 0.044) in our study population, adjusted for age, sex and pack-years of smoking using a multivariate Cox regression model. This evidence concerns the gene ALDH3B1 and lung carcinoma.