In this study, it was discovered that the expression of atrial type iii collagen and TGF-β increased in the atrial fibrillation group in the CG-induced mouse atrial fibrillation model, while the levels of plasma CRP and IL-6 increased, consistent with the aforementioned findings, indicating that atrial fibrillation, inflammation, and myocardial fibrosis are closely connected. This evidence concerns the gene IL6 and atrial fibrillation.