The negative correlation of ribosomal- and mitochondrial-associated gene sets was unique to SETD2 expression, as these genes sets were not associated with expression levels of other major tumor suppressors in lung adenocarcinoma such as TP53 or RB1, which instead correlated with DNA replication-associated gene sets (Supplementary Fig. 1E–G). Here, SETD2 is linked to lung adenocarcinoma.