ERBB2 and breast carcinoma: It has been reported that αB-crystallin, which is activated by the nuclear factor-kappa B (NF-κB) signaling cascade, is required for cell migration and invasion in HER2-positive breast cancer cells13, and that 5-FU activates transcription factors such as NF-κB and hypoxia-inducible factor-1α in cancer cells26,27.