In a cohort of 32 patients with dementia, including 20 patients with AD and 12 with FTD, the mean plasma NfL concentration measured by Ella was significantly higher than the one obtained by SiMoA (MED: 45.95 IQR: 30.60 pg/mL vs. MED: 26.95 IQR: 19.45 pg/mL; p < 0.0001) (Fig. 1A). This evidence concerns the gene NEFL and frontotemporal dementia.