Indeed, we formally identified IL-1α as a DAMP released by necrotic cardiomyocytes, promoting IL-1 receptor-dependent pro-inflammatory signaling in cardiac fibroblasts in vitro3, and we found that Il1a-KO mice had decreased myocardial and systemic inflammation in an acute model (2 h) of myocardial ischemia/reperfusion (MIR)3. Here, IL1A is linked to myocardial ischemia.