Altogether, these data indicate that IL-1α represents an important signal for early post-MI fibrotic and hypertrophic ventricular remodeling, leading to enhanced myocardial wall stress, an assumption that was further confirmed by the suppressed increase of heart weight at day 3 and day 7 after MI in IL-1α KO mice. The gene discussed is IL1A; the disease is myocardial infarction.