IL1A and myocardial infarction: To address this question, we compared myocardial inflammation and remodeling in wild type (WT) and systemic Il1a-knockout (IL-1α KO) mice, and also assessed the influence of a cardiomyocyte-specific deletion of Il1a (CmIl1a-KO mice) on delayed cardiac remodeling and dysfunction after MI in a model of permanent ligation of the left anterior descending (LAD) coronary artery.