In addition to the aforementioned genes, IL-1α KO mice also had reduced expression of the hypertrophy gene Myh7 (β-myosin heavy chain)35, a finding consistent with the cardiac hypertrophy reported in transgenic mice overexpressing IL-1α36, as well as Nppb, which encodes for the B-type natriuretic peptide. Here, NPPB is linked to cardiac hypertrophy.