Indeed, we found that, although many invadopodia, identified as actin- and cortactin-rich punctate structures, were present in in situ WM1862 melanoma cells (mean value: 13.87 ± 1.19 invadopodia/cell) none of them displayed degradative properties as reported by in situ zymography assay (Fig. 1A, see quantification of the gelatin signal in green along the yellow arrows 1, 2 and 3). The gene discussed is CTTN; the disease is melanoma.