Moreover, pretreatment of CLL cells with a blocking anti-CD47 antibody induced a significant increase of CLL cell viability in co-culture with LYNKO HS-5 but had no effect on viability in LYNWT co-culture (Fig. 6j), mechanistically confirming that THBS1 induced CLL cell death via CD47 ligation. The gene discussed is CD47; the disease is B-cell chronic lymphocytic leukemia.