Notably, the leukemic burden was significantly lower in chLyn-/- mice in comparison to Lynwt/wt mice in week 4 and remained consistently lower until week 14 (Fig. 1b), indicating that LYN-dependent functions within the non-hematopoietic microenvironment contributed to the generation of a fully leukemia supporting niche. The gene discussed is LYN; the disease is leukemia.