TINCR and Erythema: However, treatment of Tincr wild type, heterozygous and knockout mice with an erythema-inducing dose of UVB (280–315 nm) radiation revealed a significant reduction (P = 0.0393) of the UVB-induced epidermal thickening at 48 h in Tincr knockout females compared to wild type controls (Fig. 1e, f).