TINCR and head and neck squamous cell carcinoma: Moreover, and in support of a differentiation role for TINCR as a tumor suppressor, gene expression analysis of HNSCC patient samples from TCGA14 revealed an association of TINCR RNA levels with transcriptional programs linked with epithelial differentiation and keratinization (Fig. 2j–l and Supplementary Data 3, 4,, 5).