It was previously shown that the GluA2 subunit of AMPAR is highly dynamic in dendritic spines in vivo and that their dynamics are altered in the Fmr1 KO mouse (Suresh and Dunaevsky, 2017), but if learning induced translocation of AMPAR is impaired in FXS is not known. The gene discussed is FMR1; the disease is fragile X syndrome.