However, recent data using mass spectrometry to map tau posttranslational modifications in both Alzheimer’s disease and control adult brain suggests that the predicted 14-3-3 binding motifs in “tau pred” (Ser214, Ser245, and Ser352) show low-to-minimal levels of phosphorylation (Wesseling et al., 2020). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.