EIF2A and hydrops fetalis: As noted earlier for HF treatment, Gcn2iB also showed enhanced p-eIF2α even in Gcn2 KO cells, but in the Gcn2 KO cells, the induction of p-eIF2α was reduced compared to that observed in WT cells and occurred largely at the higher inhibitory Gcn2iB concentrations (Fig. 4C).