Via both proximal mechanisms, MYC drives many characteristics of the cancer cell, including elevated biomass accumulation (86), lipogenesis (87, 88), cell proliferation (89), and genomic instability (90), as well as effects on the host microenvironment that can influence metastasis (91), tumor and stromal interactions (85, 92), and immune surveillance and evasion (38). Here, MYC is linked to cancer.