MYC and acute lymphoblastic leukemia: To assess whether MYC expression affects the abundance of sialoglycans on cancer cells, we used a periodate-aminooxy ligation (42) to quantify sialic acids on the surface of MYC-driven T-ALL cells in the MYC on (no doxycycline) and off states (plus doxycycline) (SI Appendix, Fig. S1B).