Also, we observed increased frequencies of CD4+ T cells (72.5% vs. 64.7% of T cells) and decreased frequencies of CD8+ T cells (25.1% vs. 32.8% of T cells) in mice that were transplanted with St6galnac4−/− T-ALL cells compared to WT T-ALL (Fig. 3D). Here, CD8A is linked to acute lymphoblastic leukemia.