MYC and acute lymphoblastic leukemia: Here, using a conditional transgenic mouse model of MYC-induced T-ALL that expresses human MYC in a tetracycline-dependent manner (EμSRα-tTA/tet-O-MYC) (41), we asked whether MYC directs altered glycosylation and how this affects the innate antitumor immune response and tumorigenesis (SI Appendix, Fig. S1A).