The B-cell receptor (BCR) signaling pathway plays a key role in the development of hematologic B-cell-derived malignancies, including chronic lymphocytic leukemia (CLL) [1], diffuse large B-cell lymphoma (DLBCL) [2], mantle cell lymphoma (MCL) [3], and other non-Hodgkin’s lymphomas [4]. The gene discussed is BCR; the disease is mantle cell lymphoma.