Previous research has declared that metformin might alleviated HUVECs apoptosis and vascular endothelial injury by regulating FOXO protein.[22] Meanwhile, activated PI3K/Akt might regulate glycolysis through the HIF-1α pathway and reduce vascular damage under hypoxic conditions.[23] Altogether, these m6A modified lncRNAs mediated pathways could harmonize blood glucose, diminish the degree of atherosclerosis and alleviate endothelial cell dysfunction. This evidence concerns the gene HIF1A and atherosclerosis.