MAPK1 and diabetic kidney disease: Furthermore, lncRNA XIST protects podocyte from high glucose-induced cell injury by sponging miR-30 and regulating AVEN expression in diabetic nephropathy.[26] Additionally, m6A modification of lncRNAs levels has been observed in various prime aggravators of diabetic nephropathy pathogenesis.[27] The targets of XIST were involved in BCL2, STAT3, MAPK1, and VEGF, which mainly concentrate on the immune regulation, oxidative stress, inflammatory response.