These hub relevant targets may through its function of regulating cell growth, cycle, apoptosis, and angiogenesis, promoting mucous cell hyperplasia, and decreasing inflammatory cytokines release and through AGE-RAGE signaling pathway in diabetic complications, and fluid shear stress and atherosclerosis pathway to played its role in relieving inflammatory, anti-oxidative stress response, and promoting cell proliferation to improve AR. This evidence concerns the gene RENBP and atherosclerosis.