Deletion of HIF-1α has been reported to markedly impair metastasis in a mouse mammary tumor virus promoter-driven polyoma middle T antigen mouse model of breast cancer.[27] In an orthotopic xenograft model of lung cancer, the HIF-1α antagonist PX-478 effectively inhibits tumor progression.[28] Similarly, we identified a high HIF-1α protein expression in PTC tissues, the expression of HIF-1α was also related to tumor size, capsular invasion and lymph node metastasis, revealing an important role of HIF-1α in pathogenesis of PTC. This evidence concerns the gene HIF1A and lung carcinoma.