The above results demonstrated that the expressions of HIF-1α and HIF-1α/PKM2 axis (HIF-1α+/PKM2+) were significantly associated with bigger tumor size, and the expressions of HIF-1α, PKM2 and HIF-1α/PKM2 axis were all correlated with capsular invasion and lymph node metastasis. The gene discussed is HIF1A; the disease is neoplasm.