PKM and cancer: Additionally, PKM2 increases the binding of HIF-1α and the recruitment of the coactivator p300 to hypoxia-response elements on HIF-1α target genes in a positive feedback loop.[11] A large body of data indicates that HIF-1α/PKM2 loop contribute to the Warburg effect and tumor growth.[12,13] Hua et al[14] reported that the positive feedback loop of PKM2/HIFα axis paves the way to cancer-specific metabolism in response to low oxygen-glucose challenge in non-small cell lung cancer (NSCLC), and targeting this axis may present new perspectives in the prevention or treatment of NSCLC.