PKM and metastatic malignant neoplasm in the lymph nodes: Both the positive expressions of HIF-1α and PKM2 were observed more frequently in cases with capsular invasion than those of without (90.2% vs 52.6%, 85.4% vs 52.6%, both P < .05) and in cases with lymph node metastasis than those without lymph node metastasis (88.2% vs 65.4%, 88.2% vs 57.7% both P < .05).