SPP1 and cancer: Li et al further demonstrated that BRSK2 is positively associated with cancer status, has a prognostic risk for HCC, and may be involved in the regulatory mechanism of m6A methylation.[39]SPP1 is also a signature gene in HCC tissues that enhances the proliferation of tumor cells and is closely related to tumor progression.[40] More importantly, SPP1 mediates the crosstalk between HCC cells and macrophages and triggers the polarization of macrophages towards the M2 phenotype.[41] However, the association between these genes and the TRP family has rarely been studied, except for MMP1.