Another finding is that the activation of the TRP family-related gene, TRPC5 (which in this study was highly expressed in paracarcinoma tissues), may inhibit macrophage differentiation by regulating the Akt/IκB/NF-κB signaling pathway.[36] Therefore, we further speculated that TRPC5 could cause increased infiltration of M1 macrophages, thereby reducing the invasiveness of tumor cells, inhibiting their malignant phenotype, and promoting a favorable prognosis for patients with HCC. This evidence concerns the gene NFKB1 and hepatocellular carcinoma.